LRAT Antibody, FITC conjugated (PACO63349)
- SKU:
- PACO63349
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | LRAT Antibody, FITC conjugated (PACO63349) |
抗体コード: | PACO63349 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lecithin retinol acyltransferase protein (24-182AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. |
シノニム: | Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase), LRAT |
UniProt Protein Function: | LRAT: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. Defects in LRAT are a cause of Leber congenital amaurosis type 14 (LCA14). It is a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. Belongs to the H-rev107 family. |
UniProt Protein Details: | Protein type:EC 2.3.1.135; Transferase; Cofactor and Vitamin Metabolism - retinol; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q32.1 Cellular Component: multivesicular body; endoplasmic reticulum membrane; rough endoplasmic reticulum; perinuclear region of cytoplasm; integral to membrane Molecular Function:retinoic acid binding; transferase activity, transferring acyl groups; retinol binding; phosphatidylcholine-retinol O-acyltransferase activity Biological Process: positive regulation of lipid transport; phototransduction, visible light; visual perception; retinol metabolic process; retinoic acid metabolic process; retinoid metabolic process; vitamin A metabolic process Disease: Leber Congenital Amaurosis 14; Retinitis Pigmentosa |
NCBI Summary: | The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] |
UniProt Code: | O95237 |
NCBI GenInfo Identifier: | 46576867 |
NCBI Gene ID: | 9227 |
NCBI Accession: | O95237.2 |
UniProt Secondary Accession: | O95237,Q8N716, A8K983, |
UniProt Related Accession: | O95237 |
Molecular Weight: | 25,703 Da |
NCBI Full Name: | Lecithin retinol acyltransferase |
NCBI Synonym Full Names: | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) |
NCBI Official Symbol: | LRAT |
NCBI Official Synonym Symbols: | LCA14 |
NCBI Protein Information: | lecithin retinol acyltransferase |
UniProt Protein Name: | Lecithin retinol acyltransferase |
UniProt Synonym Protein Names: | Phosphatidylcholine--retinol O-acyltransferase |
Protein Family: | Lecithin retinol acyltransferase |
UniProt Gene Name: | LRAT |
UniProt Entry Name: | LRAT_HUMAN |