LPCAT2 Antibody, HRP conjugated (PACO55599)
- SKU:
- PACO55599
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | LPCAT2 Antibody, HRP conjugated (PACO55599) |
抗体コード: | PACO55599 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lysophosphatidylcholine acyltransferase 2 protein (442-544AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. |
シノニム: | Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) (Lysophosphatidic acid, acyltransferase alpha) (LPAAT-alpha), LPCAT2, AGPAT11 AYTL1 |
UniProt Protein Function: | AYTL1: Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-alkyl-phosphatidylcholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.3.1.23; EC 2.3.1.67; Acetyltransferase; Membrane protein, integral; EC 2.3.1.51 Chromosomal Location of Human Ortholog: 16q12.2 Cellular Component: Golgi membrane; endoplasmic reticulum membrane; Golgi stack; endoplasmic reticulum; integral to membrane; lipid particle Molecular Function:1-alkylglycerophosphocholine O-acetyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; calcium ion binding; 1-acylglycerol-3-phosphate O-acyltransferase activity Biological Process: platelet activating factor biosynthetic process; phospholipid metabolic process; glycerophospholipid biosynthetic process |
NCBI Summary: | This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009] |
UniProt Code: | Q7L5N7 |
NCBI GenInfo Identifier: | 74738601 |
NCBI Gene ID: | 54947 |
NCBI Accession: | Q7L5N7.1 |
UniProt Secondary Accession: | Q7L5N7,Q6MZJ6, Q9NX23, A3KBM1, |
UniProt Related Accession: | Q7L5N7 |
Molecular Weight: | 544 |
NCBI Full Name: | Lysophosphatidylcholine acyltransferase 2 |
NCBI Synonym Full Names: | lysophosphatidylcholine acyltransferase 2 |
NCBI Official Symbol: | LPCAT2 |
NCBI Official Synonym Symbols: | AYTL1; LysoPAFAT |
NCBI Protein Information: | lysophosphatidylcholine acyltransferase 2; LPCAT-2; 1-AGPAT 11; LPAAT-alpha; LPC acyltransferase 2; acyltransferase like 1; acyltransferase-like 1; 1-AGP acyltransferase 11; lysoPC acyltransferase 2; lyso-PAF acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; lysophosphatidic acid acyltransferase alpha; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-alkylglycerophosphocholine O-acetyltransferase; acyl-CoA:lysophosphatidylcholine acyltransferase 2; lyso-platelet-activating factor (PAF) acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase |
UniProt Protein Name: | Lysophosphatidylcholine acyltransferase 2 |
UniProt Synonym Protein Names: | 1-acylglycerol-3-phosphate O-acyltransferase 11 (EC:2.3.1.51); 1-AGP acyltransferase 11; 1-AGPAT 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67); Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; Acyltransferase-like 1; Lysophosphatidic acid acyltransferase alpha; LPAAT-alpha |
Protein Family: | Lysophosphatidylcholine acyltransferase |
UniProt Gene Name: | LPCAT2 |
UniProt Entry Name: | PCAT2_HUMAN |