UniProt Protein Function: | EDG7: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p22.3 Cellular Component: integral to plasma membrane; axon; plasma membrane Molecular Function:G-protein coupled receptor activity; G-protein alpha-subunit binding; phospholipid binding; lipid binding Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); activation of MAPK activity; bleb formation; positive regulation of calcium ion transport; positive regulation of collateral sprouting |
NCBI Summary: | This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBY5 |
NCBI GenInfo Identifier: | 26393418 |
NCBI Gene ID: | 23566 |
NCBI Accession: | Q9UBY5.1 |
UniProt Secondary Accession: | Q9UBY5,A0AVA3, |
UniProt Related Accession: | Q9UBY5 |
Molecular Weight: | 40,128 Da |
NCBI Full Name: | Lysophosphatidic acid receptor 3 |
NCBI Synonym Full Names: | lysophosphatidic acid receptor 3 |
NCBI Official Symbol: | LPAR3 |
NCBI Official Synonym Symbols: | EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3 |
NCBI Protein Information: | lysophosphatidic acid receptor 3; LPA receptor 3; LPA receptor EDG7; LPA-3; calcium-mobilizing lysophosphatidic acid receptor LP-A3; endothelial cell differentiation gene 7; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7; lysophosphatidic acid receptor Edg-7 |
UniProt Protein Name: | Lysophosphatidic acid receptor 3 |
UniProt Synonym Protein Names: | Lysophosphatidic acid receptor Edg-7 |
Protein Family: | Lysophosphatidic acid receptor |
UniProt Gene Name: | LPAR3 |
UniProt Entry Name: | LPAR3_HUMAN |