LMNB1 Antibody (PACO14650)
- SKU:
- PACO14650
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | LMNB1 Antibody (PACO14650) |
抗体コード: | PACO14650 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human LMNB1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14650(LMNB1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Hela cells, HT29 cells, human fetal liver tissue, 231 cells, K562 cells, human bladder transitional cell carcinoma tissue, Primary antibody: PACO14650(LMNB1 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second. | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14650(LMNB1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). |
シノニム: | lamin B1 |
UniProt Protein Function: | Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 5q23.2 Cellular Component: nucleoplasm; nuclear membrane; membrane; lamin filament; nuclear inner membrane; nuclear envelope Molecular Function:phospholipase binding; structural molecule activity Biological Process: apoptosis; cell structure disassembly during apoptosis Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant |
NCBI Summary: | This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
UniProt Code: | P20700 |
NCBI GenInfo Identifier: | 125953 |
NCBI Gene ID: | 4001 |
NCBI Accession: | P20700.2 |
UniProt Related Accession: | P20700 |
Molecular Weight: | ~ 68kDa |
NCBI Full Name: | Lamin-B1 |
NCBI Synonym Full Names: | lamin B1 |
NCBI Official Symbol: | LMNB1 |
NCBI Official Synonym Symbols: | LMN; ADLD; LMN2; LMNB |
NCBI Protein Information: | lamin-B1 |
UniProt Protein Name: | Lamin-B1 |
Protein Family: | Light-harvesting protein |
UniProt Gene Name: | LMNB1 |
UniProt Entry Name: | LMNB1_HUMAN |
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