LIG3 Antibody, FITC conjugated (PACO45980)
- SKU:
- PACO45980
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | LIG3 Antibody, FITC conjugated (PACO45980) |
抗体コード: | PACO45980 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human DNA ligase 3 protein (809-928AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair. |
シノニム: | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3), LIG3 |
UniProt Protein Function: | LIG3: Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Belongs to the ATP-dependent DNA ligase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.5.1.1; Ligase Chromosomal Location of Human Ortholog: 17q11.2-q12 Cellular Component: nucleoplasm; mitochondrion; chromosome; synaptonemal complex; nucleus Molecular Function:protein binding; DNA binding; DNA ligase activity; zinc ion binding; DNA ligase (ATP) activity; ATP binding Biological Process: mitochondrial DNA repair; mitochondrion organization and biogenesis; negative regulation of DNA recombination; V(D)J recombination; base-excision repair, DNA ligation; DNA repair; cell cycle; lagging strand elongation; double-strand break repair via nonhomologous end joining; DNA ligation; nucleotide-excision repair; base-excision repair; cell division; double-strand break repair |
NCBI Summary: | This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49916 |
NCBI GenInfo Identifier: | 251757259 |
NCBI Gene ID: | 3980 |
NCBI Accession: | P49916.2 |
UniProt Related Accession: | P49916 |
Molecular Weight: | |
NCBI Full Name: | DNA ligase 3 |
NCBI Synonym Full Names: | DNA ligase 3 |
NCBI Official Symbol: | LIG3 |
NCBI Official Synonym Symbols: | LIG2; LIG3alpha |
NCBI Protein Information: | DNA ligase 3 |
UniProt Protein Name: | DNA ligase 3 |
UniProt Synonym Protein Names: | DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3 |
Protein Family: | DNA ligase |
UniProt Gene Name: | LIG3 |
UniProt Entry Name: | DNLI3_HUMAN |