LAPTM4B Antibody, HRP conjugated (PACO58253)
- SKU:
- PACO58253
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | LAPTM4B Antibody, HRP conjugated (PACO58253) |
抗体コード: | PACO58253 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid, (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. |
シノニム: | Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta), LAPTM4B |
UniProt Protein Function: | LAPTM4B: Belongs to the LAPTM4/LAPTM5 transporter family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: integral to membrane; endomembrane system Molecular Function:protein binding Biological Process: transport |
UniProt Code: | Q86VI4 |
NCBI GenInfo Identifier: | 74714056 |
NCBI Gene ID: | 55353 |
NCBI Accession: | Q86VI4.1 |
UniProt Secondary Accession: | Q86VI4,Q3ZCV5, Q7L909, Q86VH8, Q9H060, |
UniProt Related Accession: | Q86VI4 |
Molecular Weight: | 370 |
NCBI Full Name: | Lysosomal-associated transmembrane protein 4B |
NCBI Synonym Full Names: | lysosomal protein transmembrane 4 beta |
NCBI Official Symbol: | LAPTM4B |
NCBI Official Synonym Symbols: | LC27; LAPTM4beta |
NCBI Protein Information: | lysosomal-associated transmembrane protein 4B; lysosome-associated transmembrane protein 4-beta; lysosomal associated protein transmembrane 4 beta |
UniProt Protein Name: | Lysosomal-associated transmembrane protein 4B |
UniProt Synonym Protein Names: | Lysosome-associated transmembrane protein 4-beta |
Protein Family: | Lysosomal-associated transmembrane protein |
UniProt Gene Name: | LAPTM4B |
UniProt Entry Name: | LAP4B_HUMAN |