LAMP2 Antibody (PACO27905)
- SKU:
- PACO27905
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | LAMP2 Antibody (PACO27905) |
抗体コード: | PACO27905 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Lysosome-associated membrane glycoprotein 2 protein (54-268AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot Positive WB detected in: Mouse spleen tissue, Mouse kidney tissue, Mouse brain tissue All lanes: LAMP2 antibody at 4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 45, 46 kDa Observed band size: 45 kDa . | |
Immunofluorescent analysis of HepG2 cells using PACO27905 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO27905 at dilution of 1:100. |
バックグラウンド: | Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acid, c environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. |
シノニム: | Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b), LAMP2 |
UniProt Protein Function: | LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq24 Cellular Component: phagocytic vesicle membrane; membrane; lysosome; lysosomal membrane; late endosome membrane; late endosome; plasma membrane; integral to membrane; platelet dense granule membrane Molecular Function:protein domain specific binding; enzyme binding Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation Disease: Danon Disease |
NCBI Summary: | The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008] |
UniProt Code: | P13473 |
NCBI GenInfo Identifier: | 1708854 |
NCBI Gene ID: | 3920 |
NCBI Accession: | P13473.2 |
UniProt Secondary Accession: | P13473,Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93, A8K4X5 D3DTF0, |
UniProt Related Accession: | P13473 |
Molecular Weight: | 410 |
NCBI Full Name: | Lysosome-associated membrane glycoprotein 2 |
NCBI Synonym Full Names: | lysosomal-associated membrane protein 2 |
NCBI Official Symbol: | LAMP2 |
NCBI Official Synonym Symbols: | LAMPB; CD107b; LAMP-2; LGP110 |
NCBI Protein Information: | lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B |
UniProt Protein Name: | Lysosome-associated membrane glycoprotein 2 |
UniProt Synonym Protein Names: | CD107 antigen-like family member B; CD_antigen: CD107b |
Protein Family: | Lysosome-associated membrane glycoprotein |
UniProt Gene Name: | LAMP2 |
UniProt Entry Name: | LAMP2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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