KSR1 Antibody (PACO19918)
- SKU:
- PACO19918
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | KSR1 Antibody (PACO19918) |
抗体コード: | PACO19918 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human KSR1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19918(KSR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO19918(KSR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene. Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity. |
シノニム: | kinase suppressor of ras 1 |
UniProt Protein Function: | KSR: a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; RAF family Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; protein complex Molecular Function:ATP binding; MAP-kinase scaffold activity; metal ion binding; mitogen-activated protein kinase kinase binding; protein binding; protein C-terminus binding; protein kinase activity Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway |
UniProt Code: | Q8IVT5 |
NCBI GenInfo Identifier: | 677286751 |
NCBI Gene ID: | 8844 |
NCBI Accession: | Q8IVT5.3 |
UniProt Secondary Accession: | Q8IVT5,Q13476, F8WEA9, H7BYU0, |
UniProt Related Accession: | Q8IVT5 |
Molecular Weight: | 84,697 Da |
NCBI Full Name: | Kinase suppressor of Ras 1 |
NCBI Synonym Full Names: | kinase suppressor of ras 1 |
NCBI Official Symbol: | KSR1 |
NCBI Official Synonym Symbols: | KSR; RSU2 |
NCBI Protein Information: | kinase suppressor of Ras 1 |
UniProt Protein Name: | Kinase suppressor of Ras 1 |
Protein Family: | Kinase suppressor of Ras |
UniProt Gene Name: | KSR1 |
UniProt Entry Name: | KSR1_HUMAN |
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