KRT6A Antibody, HRP conjugated (PACO27870)
- SKU:
- PACO27870
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | KRT6A Antibody, HRP conjugated (PACO27870) |
抗体コード: | PACO27870 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Keratin, type II cytoskeletal 6A protein (2-564AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
シノニム: | Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5), KRT6A, K6A KRT6D |
UniProt Protein Function: | K6a: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Associates with K16 and/or -17. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: membrane; keratin filament; nucleus Molecular Function:protein binding; structural constituent of cytoskeleton Biological Process: wound healing; positive regulation of cell proliferation; morphogenesis of an epithelium; cell differentiation Disease: Pachyonychia Congenita 3 |
NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014] |
UniProt Code: | P02538 |
NCBI GenInfo Identifier: | 1346344 |
NCBI Gene ID: | 3853 |
NCBI Accession: | P02538.3 |
UniProt Related Accession: | P02538 |
Molecular Weight: | 60kDa |
NCBI Full Name: | Keratin, type II cytoskeletal 6A |
NCBI Synonym Full Names: | keratin 6A |
NCBI Official Symbol: | KRT6A |
NCBI Official Synonym Symbols: | K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D |
NCBI Protein Information: | keratin, type II cytoskeletal 6A |
UniProt Protein Name: | Keratin, type II cytoskeletal 6A |
UniProt Synonym Protein Names: | Cytokeratin-6A; CK-6A; Cytokeratin-6D; CK-6D; Keratin-6A; K6A; Type-II keratin Kb6; Allergen: Hom s 5 |
UniProt Gene Name: | KRT6A |
UniProt Entry Name: | K2C6A_HUMAN |