KRT17 Antibody, Biotin conjugated (PACO27856)
- SKU:
- PACO27856
- Product type:
- Antibody
- Reactivity:
- Bovine
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | KRT17 Antibody, Biotin conjugated (PACO27856) |
抗体コード: | PACO27856 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Bovine |
免疫原: | Recombinant Bovine Keratin, type I cytoskeletal 17 protein (1-441AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-α in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
シノニム: | Keratin, type I cytoskeletal 17 (Cytokeratin-17) (CK-17) (Keratin-17) (K17), KRT17 |
UniProt Protein Function: | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | A1L595 |
NCBI GenInfo Identifier: | 157427776 |
NCBI Gene ID: | 281889 |
NCBI Accession: | NP_001098792.1 |
UniProt Secondary Accession: | A1L595,A5PJJ6 |
UniProt Related Accession: | A1L595 |
Molecular Weight: | 64.7 kDa |
NCBI Full Name: | keratin, type I cytoskeletal 17 |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | KRT17 |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | keratin, type I cytoskeletal 17 |
UniProt Protein Name: | Keratin, type I cytoskeletal 17 |
UniProt Synonym Protein Names: | Cytokeratin-17; CK-17; Keratin-17; K17 |
Protein Family: | Keratin |
UniProt Gene Name: | KRT17 |
UniProt Entry Name: | K1C17_BOVIN |