UniProt Protein Function: | MLL5: Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic- acid-induced granulopoiesis by acting as a coactivator of RAR- alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 7 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.1.1.43; Transcription, coactivator/corepressor; Methyltransferase, protein lysine; Cell cycle regulation; Methyltransferase Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: nucleoplasm; intercellular bridge; intracellular membrane-bound organelle; cytoplasm; plasma membrane; nuclear speck Molecular Function:protein binding; enzyme binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); transcription coactivator activity Biological Process: retinoic acid receptor signaling pathway; establishment and/or maintenance of chromatin architecture; neutrophil activation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of granulocyte differentiation; histone H3-K4 methylation; DNA methylation; neutrophil mediated immunity; erythrocyte differentiation; cell cycle arrest |
NCBI Summary: | This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8IZD2 |
NCBI GenInfo Identifier: | 74723669 |
NCBI Gene ID: | 55904 |
NCBI Accession: | Q8IZD2.1 |
UniProt Secondary Accession: | Q8IZD2,Q6P5Y2, Q6PKG4, Q6T316, Q86TI3, Q86W12, Q86WG0 Q86WL2, Q8IV78, B6ZDE4, B6ZDM3, M4K8J3, |
UniProt Related Accession: | Q8IZD2 |
Molecular Weight: | 1858 |
NCBI Full Name: | Histone-lysine N-methyltransferase 2E |
NCBI Synonym Full Names: | lysine (K)-specific methyltransferase 2E |
NCBI Official Symbol: | KMT2E |
NCBI Official Synonym Symbols: | MLL5; NKp44L; HDCMC04P |
NCBI Protein Information: | histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; myeloid/lymphoid or mixed-lineage leukemia protein 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) |
UniProt Protein Name: | Histone-lysine N-methyltransferase 2E |
UniProt Synonym Protein Names: | Myeloid/lymphoid or mixed-lineage leukemia protein 5 |
Protein Family: | Histone-lysine N-methyltransferase |
UniProt Gene Name: | KMT2E |
UniProt Entry Name: | KMT2E_HUMAN |