KLHL13 Antibody (PACO45246)
- SKU:
- PACO45246
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KLHL13 Antibody (PACO45246) |
抗体コード: | PACO45246 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Kelch-like protein 13 protein (1-260AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: KLHL13 antibody at 5.06µg/ml + Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 74, 70, 73, 75 kDa. Observed band size: 74 kDa.. | |
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO45246 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO45246 at dilution of 1:100. |
バックグラウンド: | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. |
シノニム: | Kelch-like protein 13 (BTB and kelch domain-containing protein 2), KLHL13, BKLHD2 KIAA1309 |
UniProt Protein Function: | KLHL13: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: Xq23-q24 Molecular Function:ubiquitin-protein ligase activity Biological Process: mitosis; cytokinesis; protein ubiquitination |
NCBI Summary: | This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
UniProt Code: | Q9P2N7 |
NCBI GenInfo Identifier: | 269973869 |
NCBI Gene ID: | 90293 |
NCBI Accession: | NP_001161774.1 |
UniProt Secondary Accession: | Q9P2N7,Q6P2E3, Q96QI7, Q9UDN9, B3KV78, B3KWM7, B7Z3S9 B7Z5P2, B7Z802, D3DWH6, |
UniProt Related Accession: | Q9P2N7 |
Molecular Weight: | 74,630 Da |
NCBI Full Name: | kelch-like protein 13 isoform d |
NCBI Synonym Full Names: | kelch-like family member 13 |
NCBI Official Symbol: | KLHL13 |
NCBI Official Synonym Symbols: | BKLHD2 |
NCBI Protein Information: | kelch-like protein 13; kelch-like 13; BTB and kelch domain containing 2 |
UniProt Protein Name: | Kelch-like protein 13 |
UniProt Synonym Protein Names: | BTB and kelch domain-containing protein 2 |
Protein Family: | Kelch-like protein |
UniProt Gene Name: | KLHL13 |
UniProt Entry Name: | KLH13_HUMAN |