KIF1C Antibody (PACO16586)
- SKU:
- PACO16586
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KIF1C Antibody (PACO16586) |
抗体コード: | PACO16586 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human KIF1C |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human sarcoma tissue using PACO16586(KIF1C Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO16586(KIF1C Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16586(KIF1C Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell . Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis . KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons . Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid, protein with abundant expression in heart and skeletal muscle . Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta . In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance. |
シノニム: | kinesin family member 1C |
UniProt Protein Function: | KIF1C: Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility. Belongs to the kinesin-like protein family. Unc-104 subfamily. |
UniProt Protein Details: | Protein type:Microtubule-binding; Motor Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: endoplasmic reticulum; kinesin complex Molecular Function:ATPase activity; microtubule motor activity; motor activity; protein binding Biological Process: cytoskeleton-dependent intracellular transport; microtubule-based movement Disease: Spastic Ataxia 2, Autosomal Recessive |
NCBI Summary: | The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014] |
UniProt Code: | O43896 |
NCBI GenInfo Identifier: | 40254834 |
NCBI Gene ID: | 10749 |
NCBI Accession: | NP_006603.2 |
UniProt Secondary Accession: | O43896,O75186, Q5U618, D3DTL6, |
UniProt Related Accession: | O43896 |
Molecular Weight: | 122,947 Da |
NCBI Full Name: | kinesin-like protein KIF1C |
NCBI Synonym Full Names: | kinesin family member 1C |
NCBI Official Symbol: | KIF1C |
NCBI Official Synonym Symbols: | SAX2; LTXS1; SATX2; SPAX2; SPG58 |
NCBI Protein Information: | kinesin-like protein KIF1C |
UniProt Protein Name: | Kinesin-like protein KIF1C |
Protein Family: | Kinesin-like protein |
UniProt Gene Name: | KIF1C |