KIAA0319 Antibody, Biotin conjugated (PACO57047)
- SKU:
- PACO57047
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | KIAA0319 Antibody, Biotin conjugated (PACO57047) |
抗体コード: | PACO57047 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Dyslexia-associated protein KIAA0319 protein (153-268AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. |
シノニム: | Dyslexia-associated protein KIAA0319, KIAA0319 |
UniProt Protein Function: | KIAA0319: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. Defects in KIAA0319 may be a cause of susceptibility to dyslexia type 2 (DYX2); also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. A lower expression is associated with the risk haplotype. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: early endosome membrane; early endosome; plasma membrane; integral to membrane Molecular Function:protein binding Biological Process: neuron migration Disease: Dyslexia, Susceptibility To, 2 |
NCBI Summary: | This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in this gene are associated with dyslexia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
UniProt Code: | Q5VV43 |
NCBI GenInfo Identifier: | 270265853 |
NCBI Gene ID: | 9856 |
NCBI Accession: | NP_001161846.1 |
UniProt Secondary Accession: | Q5VV43,Q9UJC8, Q9Y4G7, A7MD37, B2RTU7, B4DHA7, B4DK75 B7ZML3, F5H123, |
UniProt Related Accession: | Q5VV43 |
Molecular Weight: | 117,763 Da |
NCBI Full Name: | dyslexia-associated protein KIAA0319 isoform b |
NCBI Synonym Full Names: | KIAA0319 |
NCBI Official Symbol: | KIAA0319 |
NCBI Official Synonym Symbols: | DYX2; NMIG; DYLX2 |
NCBI Protein Information: | dyslexia-associated protein KIAA0319; neuronal migration; dyslexia susceptibility 2 |
UniProt Protein Name: | Dyslexia-associated protein KIAA0319 |
Protein Family: | Dyslexia-associated protein |
UniProt Gene Name: | KIAA0319 |
UniProt Entry Name: | K0319_HUMAN |