UniProt Protein Function: | Kv11.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:voltage-gated potassium channel activity; signal transducer activity Biological Process: synaptic transmission; regulation of membrane potential; signal transduction |
NCBI Summary: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9H252 |
NCBI GenInfo Identifier: | 524550850 |
NCBI Gene ID: | 81033 |
NCBI Accession: | NP_001265848.1 |
UniProt Secondary Accession: | Q9H252,Q9BRD7, |
UniProt Related Accession: | Q9H252 |
Molecular Weight: | 56,298 Da |
NCBI Full Name: | potassium voltage-gated channel subfamily H member 6 isoform 3 |
NCBI Synonym Full Names: | potassium channel, voltage gated eag related subfamily H, member 6 |
NCBI Official Symbol: | KCNH6 |
NCBI Official Synonym Symbols: | ERG2; ERG-2; HERG2; Kv11.2; hERG-2 |
NCBI Protein Information: | potassium voltage-gated channel subfamily H member 6 |
UniProt Protein Name: | Potassium voltage-gated channel subfamily H member 6 |
UniProt Synonym Protein Names: | Ether-a-go-go-related gene potassium channel 2; ERG-2; Eag-related protein 2; Ether-a-go-go-related protein 2; hERG-2; hERG2; Voltage-gated potassium channel subunit Kv11.2 |
Protein Family: | Potassium voltage-gated channel subfamily |
UniProt Gene Name: | KCNH6 |
UniProt Entry Name: | KCNH6_HUMAN |