JAG1 Antibody (PACO02087)
- SKU:
- PACO02087
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | JAG1 Antibody |
抗体コード: | PACO02087 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the Internal region of human Jagged1. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | JAG1; JAGL1; Protein jagged-1; Jagged1; hJ1; CD339 |
UniProt Protein Function: | JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 20p12.2 Cellular Component: adherens junction; apical plasma membrane; membrane; plasma membrane Molecular Function:Notch binding; phospholipid binding; protein binding Biological Process: Notch receptor processing; Notch signaling pathway; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; T cell mediated immunity Disease: Alagille Syndrome 1; Tetralogy Of Fallot |
NCBI Summary: | The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] |
UniProt Code: | P78504 |
NCBI GenInfo Identifier: | 20455033 |
NCBI Gene ID: | 182 |
NCBI Accession: | P78504.3 |
UniProt Secondary Accession: | P78504,O14902, O15122, Q15816, A0AV43, B4DYR1, E9PCF9 |
UniProt Related Accession: | P78504 |
Molecular Weight: | 134kDa |
NCBI Full Name: | Protein jagged-1 |
NCBI Synonym Full Names: | jagged 1 |
NCBI Official Symbol: | JAG1 |
NCBI Official Synonym Symbols: | AGS; AHD; AWS; HJ1; AGS1; CD339; JAGL1 |
NCBI Protein Information: | protein jagged-1 |
UniProt Protein Name: | Protein jagged-1 |
UniProt Synonym Protein Names: | CD_antigen: CD339 |
Protein Family: | Protein jagged |
UniProt Gene Name: | JAG1 |