IRAK1 Antibody (PACO05908)
- SKU:
- PACO05908
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | IRAK1 Antibody (PACO05908) |
抗体コード: | PACO05908 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:5000, IHC:1:100-1:300 |
反応性: | Human |
免疫原: | Synthesized peptide derived from human IRAK-1 around the non-phosphorylation site of S376. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | IRAK1; IRAK; Interleukin-1 receptor-associated kinase 1; IRAK-1 |
UniProt Protein Function: | IRAK1: a TKL kinase of the IRAK family. Involved in Toll/IL-1 signaling. One of two putative serine/threonine kinases that become associated with the interleukin-1 receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Extensively phosphorylated after its association with IL1-R-1. Polyubiquitinated; after cell stimulation with IL-1-beta. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Three isoforms of the human protein and produced by alternative splicing. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. |
UniProt Protein Details: | Protein type:Protein kinase, TKL; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; IRAK family Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cytoplasm; cytosol; endosome membrane; lipid particle; nucleus; plasma membrane Molecular Function:kinase activity; NF-kappaB-inducing kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; inhibition of NF-kappaB transcription factor; JNK cascade; lipopolysaccharide-mediated signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of MAP kinase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein oligomerization; regulation of cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway |
NCBI Summary: | This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P51617 |
NCBI GenInfo Identifier: | 8928535 |
NCBI Gene ID: | 3654 |
NCBI Accession: | P51617.2 |
UniProt Secondary Accession: | P51617,Q7Z5V4, Q96C06, Q96RL2, D3DWW3, D3DWW4, |
UniProt Related Accession: | P51617 |
Molecular Weight: | 68,022 Da |
NCBI Full Name: | Interleukin-1 receptor-associated kinase 1 |
NCBI Synonym Full Names: | interleukin 1 receptor associated kinase 1 |
NCBI Official Symbol: | IRAK1 |
NCBI Official Synonym Symbols: | IRAK; pelle |
NCBI Protein Information: | interleukin-1 receptor-associated kinase 1 |
UniProt Protein Name: | Interleukin-1 receptor-associated kinase 1 |
Protein Family: | Interleukin-1 receptor-associated kinase |
UniProt Gene Name: | IRAK1 |
UniProt Entry Name: | IRAK1_HUMAN |