IMPDH2 Antibody (PACO16544)
- SKU:
- PACO16544
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IMPDH2 Antibody (PACO16544) |
抗体コード: | PACO16544 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human IMPDH2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16544(IMPDH2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO16544(IMPDH2 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16544(IMPDH2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. |
シノニム: | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
UniProt Protein Function: | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
NCBI Summary: | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] |
UniProt Code: | P12268 |
NCBI GenInfo Identifier: | 124419 |
NCBI Gene ID: | 3615 |
NCBI Accession: | P12268.2 |
UniProt Secondary Accession: | P12268,Q6LEF3, |
UniProt Related Accession: | P12268 |
Molecular Weight: | 55,805 Da |
NCBI Full Name: | Inosine-5'-monophosphate dehydrogenase 2 |
NCBI Synonym Full Names: | inosine monophosphate dehydrogenase 2 |
NCBI Official Symbol: | IMPDH2 |
NCBI Official Synonym Symbols: | IMPD2; IMPDH-II |
NCBI Protein Information: | inosine-5'-monophosphate dehydrogenase 2 |
UniProt Protein Name: | Inosine-5'-monophosphate dehydrogenase 2 |
UniProt Synonym Protein Names: | IMPDH-II |
UniProt Gene Name: | IMPDH2 |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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