UniProt Protein Function: | IL1RAP: Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q28 Cellular Component: membrane; integral to plasma membrane; extracellular region; plasma membrane Molecular Function:signal transducer activity; interleukin-1 receptor activity Biological Process: interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; innate immune response; immune response; protein complex assembly; inflammatory response |
NCBI Summary: | Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009] |
UniProt Code: | Q9NPH3 |
NCBI GenInfo Identifier: | 34222652 |
NCBI Gene ID: | 3556 |
NCBI Accession: | Q9NPH3.2 |
UniProt Secondary Accession: | Q9NPH3,O14915, Q86WJ7, B1NLD0, D3DNW0, |
UniProt Related Accession: | Q9NPH3 |
Molecular Weight: | 570 |
NCBI Full Name: | Interleukin-1 receptor accessory protein |
NCBI Synonym Full Names: | interleukin 1 receptor accessory protein |
NCBI Official Symbol: | IL1RAP |
NCBI Official Synonym Symbols: | IL1R3; C3orf13; IL-1RAcP |
NCBI Protein Information: | interleukin-1 receptor accessory protein; IL-1R3; interleukin-1 receptor 3; IL-1 receptor accessory protein; interleukin-1 receptor accessory protein beta |
UniProt Protein Name: | Interleukin-1 receptor accessory protein |
UniProt Synonym Protein Names: | Interleukin-1 receptor 3; IL-1R-3; IL-1R3 |
Protein Family: | Interleukin-1 receptor accessory protein |
UniProt Gene Name: | IL1RAP |
UniProt Entry Name: | IL1AP_HUMAN |