IDO1 Antibody, Biotin conjugated (PACO27496)
- SKU:
- PACO27496
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | IDO1 Antibody, Biotin conjugated (PACO27496) |
抗体コード: | PACO27496 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Indoleamine 2,3-dioxygenase 1 protein (1-403AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
シノニム: | Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase), IDO1, IDO INDO |
UniProt Protein Function: | INDO: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; Cell cycle regulation; EC 1.13.11.52; Oxidoreductase Chromosomal Location of Human Ortholog: 8p12-p11 Cellular Component: stereocilium bundle; smooth muscle contractile fiber; cytosol Molecular Function:electron carrier activity; metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activity Biological Process: regulation of activated T cell proliferation; positive regulation of T-helper 2 type immune response; negative regulation of interleukin-10 production; positive regulation of chronic inflammatory response; tryptophan catabolic process to kynurenine; positive regulation of interleukin-12 production; response to lipopolysaccharide; female pregnancy; negative regulation of T cell proliferation; cytokine production during acute inflammatory response; multicellular organismal response to stress; tryptophan catabolic process; positive regulation of T cell tolerance induction |
NCBI Summary: | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] |
UniProt Code: | P14902 |
NCBI GenInfo Identifier: | 123948 |
NCBI Gene ID: | 3620 |
NCBI Accession: | P14902.1 |
UniProt Related Accession: | P14902 |
Molecular Weight: | 45kDa |
NCBI Full Name: | Indoleamine 2,3-dioxygenase 1 |
NCBI Synonym Full Names: | indoleamine 2,3-dioxygenase 1 |
NCBI Official Symbol: | IDO1 |
NCBI Official Synonym Symbols: | IDO; INDO; IDO-1 |
NCBI Protein Information: | indoleamine 2,3-dioxygenase 1 |
UniProt Protein Name: | Indoleamine 2,3-dioxygenase 1 |
UniProt Synonym Protein Names: | Indoleamine-pyrrole 2,3-dioxygenase |
Protein Family: | L-isoleucine-4-hydroxylase |
UniProt Gene Name: | IDO1 |
UniProt Entry Name: | I23O1_HUMAN |