HTR2C Antibody (PACO19261)
- SKU:
- PACO19261
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | HTR2C Antibody (PACO19261) |
抗体コード: | PACO19261 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human HTR2C |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 60 μg, Lane: Jurkat cells, Primary antibody: PACO19261(HTR2C Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
バックグラウンド: | Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. |
シノニム: | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled |
UniProt Protein Function: | 5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system. |
UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: Xq23 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:5-HT2 receptor activity; drug binding; neurotransmitter receptor activity; serotonin binding; serotonin receptor activity Biological Process: behavioral fear response; cellular calcium ion homeostasis; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of phosphatidylinositol biosynthetic process; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of neurological process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; serotonin receptor, phospholipase C activating pathway; synaptic transmission |
NCBI Summary: | This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015] |
UniProt Code: | P28335 |
NCBI GenInfo Identifier: | 112816 |
NCBI Gene ID: | 3358 |
NCBI Accession: | P28335.1 |
UniProt Secondary Accession: | P28335,Q5VUF8, Q9NP28, B1AMW4, |
UniProt Related Accession: | P28335 |
Molecular Weight: | 52kDa |
NCBI Full Name: | 5-hydroxytryptamine receptor 2C |
NCBI Synonym Full Names: | 5-hydroxytryptamine receptor 2C |
NCBI Official Symbol: | HTR2C |
NCBI Official Synonym Symbols: | HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C |
NCBI Protein Information: | 5-hydroxytryptamine receptor 2C |
UniProt Protein Name: | 5-hydroxytryptamine receptor 2C |
UniProt Synonym Protein Names: | 5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C |
Protein Family: | 5-hydroxytryptamine receptor |
UniProt Gene Name: | HTR2C |