UniProt Protein Function: | HSD17B12: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Oxidoreductase; Lipid Metabolism - androgen and estrogen; EC 1.1.1.62; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: extracellular matrix; endoplasmic reticulum membrane; integral to membrane Molecular Function:heparin binding; collagen binding; estradiol 17-beta-dehydrogenase activity; protein binding; fibronectin binding Biological Process: extracellular matrix organization and biogenesis; triacylglycerol biosynthetic process; cellular lipid metabolic process; estrogen biosynthetic process; fatty acid biosynthetic process |
NCBI Summary: | This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011] |
UniProt Code: | Q53GQ0 |
NCBI GenInfo Identifier: | 7705855 |
NCBI Gene ID: | 51144 |
NCBI Accession: | NP_057226.1 |
UniProt Secondary Accession: | Q53GQ0,Q96JU2, Q9Y6G8, A8K9B0, D3DR23, |
UniProt Related Accession: | Q53GQ0 |
Molecular Weight: | 34,324 Da |
NCBI Full Name: | estradiol 17-beta-dehydrogenase 12 |
NCBI Synonym Full Names: | hydroxysteroid (17-beta) dehydrogenase 12 |
NCBI Official Symbol: | HSD17B12 |
NCBI Official Synonym Symbols: | KAR; SDR12C1 |
NCBI Protein Information: | estradiol 17-beta-dehydrogenase 12; 17-beta-HSD 12; 17beta-HSD type 12; 3-ketoacyl-CoA reductase; steroid dehydrogenase homolog; 17-beta-hydroxysteroid dehydrogenase 12; short chain dehydrogenase/reductase family 12C, member 1 |
UniProt Protein Name: | Estradiol 17-beta-dehydrogenase 12 |
UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase 12; 17-beta-HSD 12; 3-ketoacyl-CoA reductase |
Protein Family: | Very-long-chain 3-oxoacyl-CoA reductase |
UniProt Gene Name: | HSD17B12 |
UniProt Entry Name: | DHB12_HUMAN |