HMGB3 Antibody, FITC conjugated (PACO55544)
- SKU:
- PACO55544
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | HMGB3 Antibody, FITC conjugated (PACO55544) |
抗体コード: | PACO55544 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human High mobility group protein B3 protein (1-103AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acid, by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). |
シノニム: | High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4), HMGB3, HMG2A HMG4 |
UniProt Protein Function: | HMGB3: Binds preferentially single-stranded DNA and unwinds double stranded DNA. Belongs to the HMGB family. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq28 Molecular Function:DNA bending activity; double-stranded DNA binding; four-way junction DNA binding; protein binding Biological Process: DNA geometric change; DNA recombination; multicellular organismal development Disease: Microphthalmia, Syndromic 13 |
NCBI Summary: | This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | O15347 |
NCBI GenInfo Identifier: | 85701353 |
NCBI Gene ID: | 3149 |
NCBI Accession: | O15347.4 |
UniProt Secondary Accession: | O15347,O95556, Q6NS40, |
UniProt Related Accession: | O15347 |
Molecular Weight: | 22,980 Da |
NCBI Full Name: | High mobility group protein B3 |
NCBI Synonym Full Names: | high mobility group box 3 |
NCBI Official Symbol: | HMGB3 |
NCBI Official Synonym Symbols: | HMG4; HMG-4; HMG2A; HMG-2a |
NCBI Protein Information: | high mobility group protein B3 |
UniProt Protein Name: | High mobility group protein B3 |
UniProt Synonym Protein Names: | High mobility group protein 2a; HMG-2a; High mobility group protein 4; HMG-4 |
Protein Family: | High mobility group protein |
UniProt Gene Name: | HMGB3 |