HLA-DOB Antibody (PACO00916)
- SKU:
- PACO00916
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | HLA-DOB Antibody |
抗体コード: | PACO00916 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | WB:1:500-1:2000 |
反応性: | Human |
免疫原: | synthesized peptide derived from the N-terminal region of human HLA-DOBeta. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | HLA-DOB; HLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB |
UniProt Protein Function: | HLA-DOB: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Belongs to the MHC class II family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.32 Cellular Component: lysosomal membrane; lysosome; MHC class II protein complex Molecular Function:MHC class II receptor activity Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of antigen processing and presentation of peptide antigen via MHC class II |
NCBI Summary: | HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
UniProt Code: | P13765 |
NCBI GenInfo Identifier: | 122261 |
NCBI Gene ID: | 3112 |
NCBI Accession: | P13765.1 |
UniProt Secondary Accession: | P13765,Q29746, Q29825, Q6FHC2, B0V0Y0, |
UniProt Related Accession: | P13765 |
Molecular Weight: | 31kDa |
NCBI Full Name: | HLA class II histocompatibility antigen, DO beta chain |
NCBI Synonym Full Names: | major histocompatibility complex, class II, DO beta |
NCBI Official Symbol: | HLA-DOB |
NCBI Official Synonym Symbols: | DOB; HLA_DOB |
NCBI Protein Information: | HLA class II histocompatibility antigen, DO beta chain |
UniProt Protein Name: | HLA class II histocompatibility antigen, DO beta chain |
UniProt Synonym Protein Names: | MHC class II antigen DOB |
Protein Family: | HLA class II histocompatibility antigen |
UniProt Gene Name: | HLA-DOB |