HDAC8 Antibody, Biotin conjugated (PACO51613)
- SKU:
- PACO51613
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | HDAC8 Antibody, Biotin conjugated (PACO51613) |
抗体コード: | PACO51613 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Histone deacetylase 8 protein (1-377AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. |
シノニム: | Histone deacetylase 8 (HD8) (EC 3.5.1.98), HDAC8, HDACL1 |
UniProt Protein Function: | HDAC8: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility. Belongs to the histone deacetylase family. HD type 1 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.5.1.98; Hydrolase Chromosomal Location of Human Ortholog: Xq13 Cellular Component: nucleoplasm; nuclear chromosome; histone deacetylase complex; cytoplasm; plasma membrane; cytosol; nucleus Molecular Function:NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor binding Biological Process: chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; sister chromatid cohesion; mitotic cell cycle; chromatin modification; negative regulation of transcription from RNA polymerase II promoter Disease: Wilson-turner X-linked Mental Retardation Syndrome |
NCBI Summary: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q9BY41 |
NCBI GenInfo Identifier: | 29839394 |
NCBI Gene ID: | 55869 |
NCBI Accession: | Q9BY41.2 |
UniProt Secondary Accession: | Q9BY41,Q86VC8, Q9NP76, Q9NYH4, A6ND12, A6ND61, A6NET3 A6NJR3, A8MQ62, B4DKN0, B4DV22, |
UniProt Related Accession: | Q9BY41 |
Molecular Weight: | 377 |
NCBI Full Name: | Histone deacetylase 8 |
NCBI Synonym Full Names: | histone deacetylase 8 |
NCBI Official Symbol: | HDAC8 |
NCBI Official Synonym Symbols: | HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1 |
NCBI Protein Information: | histone deacetylase 8; histone deacetylase-like 1 |
UniProt Protein Name: | Histone deacetylase 8 |
UniProt Gene Name: | HDAC8 |
UniProt Entry Name: | HDAC8_HUMAN |