HDAC1 Antibody (PACO09691)
- SKU:
- PACO09691
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | HDAC1 Antibody (PACO09691) |
抗体コード: | PACO09691 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human HDAC1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | histone deacetylase 1;HDAC1;DKFZp686H12203;GON-10;HD1;RPD3;RPD3L1 ; |
UniProt Protein Function: | HDAC1: a transcriptional regulator of the histone deacetylase family, subfamily 1. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; EC 3.5.1.98; Hydrolase Chromosomal Location of Human Ortholog: 1p34 Cellular Component: chromatin; cytoplasm; cytosol; histone deacetylase complex; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex; Sin3 complex Molecular Function:deacetylase activity; enzyme binding; histone deacetylase activity; histone deacetylase binding; NF-kappaB binding; nucleosomal DNA binding; protein binding; protein deacetylase activity; protein N-terminus binding; transcription activator binding; transcription factor activity; transcription factor binding Biological Process: ATP-dependent chromatin remodeling; blood coagulation; chromatin modification; chromatin remodeling; circadian regulation of gene expression; embryonic digit morphogenesis; epidermal cell differentiation; histone deacetylation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis of dentine-containing teeth; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid deacetylation |
NCBI Summary: | Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13547 |
NCBI GenInfo Identifier: | 2498443 |
NCBI Gene ID: | 3065 |
NCBI Accession: | Q13547.1 |
UniProt Secondary Accession: | Q13547,Q92534, |
UniProt Related Accession: | Q13547 |
Molecular Weight: | 55,103 Da |
NCBI Full Name: | Histone deacetylase 1 |
NCBI Synonym Full Names: | histone deacetylase 1 |
NCBI Official Symbol: | HDAC1 |
NCBI Official Synonym Symbols: | HD1; RPD3; GON-10; RPD3L1 |
NCBI Protein Information: | histone deacetylase 1 |
UniProt Protein Name: | Histone deacetylase 1 |
UniProt Gene Name: | HDAC1 |
UniProt Entry Name: | HDAC1_HUMAN |