GRK6 Antibody (PACO43519)
- SKU:
- PACO43519
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GRK6 Antibody (PACO43519) |
抗体コード: | PACO43519 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human G protein-coupled receptor kinase 6 protein (1-170AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO43519 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43519 at dilution of 1:100. |
バックグラウンド: | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
シノニム: | G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6), GRK6, GPRK6 |
UniProt Protein Function: | GRK6: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Widely expressed. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.7.11.16; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; GRK family; GRK subfamily Chromosomal Location of Human Ortholog: 5q35 Cellular Component: membrane Molecular Function:G-protein coupled receptor kinase activity; protein binding; ATP binding Biological Process: Wnt receptor signaling pathway; protein amino acid phosphorylation; regulation of G-protein coupled receptor protein signaling pathway |
NCBI Summary: | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P43250 |
NCBI GenInfo Identifier: | 20141386 |
NCBI Gene ID: | 2870 |
NCBI Accession: | P43250.2 |
UniProt Secondary Accession: | P43250,O60541, Q13652, |
UniProt Related Accession: | P43250 |
Molecular Weight: | 64,294 Da |
NCBI Full Name: | G protein-coupled receptor kinase 6 |
NCBI Synonym Full Names: | G protein-coupled receptor kinase 6 |
NCBI Official Symbol: | GRK6 |
NCBI Official Synonym Symbols: | GPRK6 |
NCBI Protein Information: | G protein-coupled receptor kinase 6 |
UniProt Protein Name: | G protein-coupled receptor kinase 6 |
UniProt Synonym Protein Names: | G protein-coupled receptor kinase GRK6 |
Protein Family: | G protein-coupled receptor kinase |
UniProt Gene Name: | GRK6 |
UniProt Entry Name: | GRK6_HUMAN |