UniProt Protein Function: | GluR5: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; plasma membrane; cell junction Molecular Function:extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity Biological Process: synaptic transmission, glutamatergic; nervous system development; regulation of synaptic transmission, glutamatergic; central nervous system development; glutamate signaling pathway; positive regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; regulation of inhibitory postsynaptic membrane potential; synaptic transmission; behavioral response to pain; transport; ionotropic glutamate receptor signaling pathway; adult behavior; regulation of excitatory postsynaptic membrane potential; positive regulation of gamma-aminobutyric acid secretion |
NCBI Summary: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P39086 |
NCBI GenInfo Identifier: | 729597 |
NCBI Gene ID: | 2897 |
NCBI Accession: | P39086.1 |
UniProt Secondary Accession: | P39086,Q13001, Q86SU9, |
UniProt Related Accession: | P39086 |
Molecular Weight: | 102,631 Da |
NCBI Full Name: | Glutamate receptor ionotropic, kainate 1 |
NCBI Synonym Full Names: | glutamate receptor, ionotropic, kainate 1 |
NCBI Official Symbol: | GRIK1 |
NCBI Official Synonym Symbols: | EAA3; EEA3; GLR5; GLUR5; GluK1 |
NCBI Protein Information: | glutamate receptor ionotropic, kainate 1; gluR-5; glutamate receptor 5; excitatory amino acid receptor 3 |
UniProt Protein Name: | Glutamate receptor ionotropic, kainate 1 |
UniProt Synonym Protein Names: | Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GluR5 |
Protein Family: | Glutamate receptor ionotropic |
UniProt Gene Name: | GRIK1 |
UniProt Entry Name: | GRIK1_HUMAN |