GRIA3 Antibody (PACO21090)
- SKU:
- PACO21090
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GRIA3 Antibody (PACO21090) |
抗体コード: | PACO21090 |
サイズ: | 100ul(100ug) |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant protein of human GRIA3 |
憲法: | Liquid |
ストレージバッファ: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of brian cell lysate using GRIA3 antibody. |
バックグラウンド: | AMPA- ( α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, , kainite- and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Post-transcriptional modifications (alternative splicing and nuclear RNA editing) and post-translational modifications (glycosylation, phoshorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. GluR 3 knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP). In contrast, GluR 2/3 double knockout mice are impaired in basal synaptic transmission. Aberrant GluR 3 expression or activity is implicated in a number of diseases, including autoimmune epilepsy, X-linked mental retardation, Retts syndrome, amyotrophic lateral sclerosis and Alzheimer disease. |
シノニム: | GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3 |
UniProt Protein Function: | GluR3: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Interacts with protein kinase C-alpha binding protein. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated Chromosomal Location of Human Ortholog: Xq25 Cellular Component: postsynaptic membrane; dendrite; plasma membrane; cell junction Molecular Function:extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Biological Process: synaptic transmission, glutamatergic; synaptic transmission; transport; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway Disease: Mental Retardation, X-linked, Syndromic, Wu Type |
NCBI Summary: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008] |
UniProt Code: | P42263 |
NCBI GenInfo Identifier: | 77416864 |
NCBI Gene ID: | 2892 |
NCBI Accession: | P42263.2 |
UniProt Secondary Accession: | P42263,Q4VXD5, Q4VXD6, Q9HDA0, Q9HDA1, Q9HDA2, Q9P0H1 D3DTF1, |
UniProt Related Accession: | P42263 |
Molecular Weight: | 101,228 Da |
NCBI Full Name: | Glutamate receptor 3 |
NCBI Synonym Full Names: | glutamate receptor, ionotropic, AMPA 3 |
NCBI Official Symbol: | GRIA3 |
NCBI Official Synonym Symbols: | GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3 |
NCBI Protein Information: | glutamate receptor 3; gluR-3; dJ1171F9.1; glutamate receptor C; glutamate receptor subunit 3; AMPA-selective glutamate receptor 3; glutamate receptor, ionotrophic, AMPA 3 |
UniProt Protein Name: | Glutamate receptor 3 |
UniProt Synonym Protein Names: | AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; GluA3 |
Protein Family: | Glutamate receptor |
UniProt Gene Name: | GRIA3 |
UniProt Entry Name: | GRIA3_HUMAN |