UniProt Protein Function: | GALNT9: a glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. Two alternatively spliced human isoforms have been described.Protein type: Transferase; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; EC 2.4.1.41Chromosomal Location of Human Ortholog: 12q24.33Cellular Component: Golgi membraneMolecular Function: polypeptide N-acetylgalactosaminyltransferase activityBiological Process: O-glycan processing |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. This gene is expressed specifically in the brain, with highest expression in the cerebellum. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HCQ5 |
NCBI GenInfo Identifier: | 143811393 |
NCBI Gene ID: | 50614 |
NCBI Accession: | Q9HCQ5.3 |
UniProt Secondary Accession: | Q9HCQ5,Q52LR8, Q6NT54, Q8NFR1 |
UniProt Related Accession: | Q9HCQ5 |
Molecular Weight: | 27,211 Da |
NCBI Full Name: | Polypeptide N-acetylgalactosaminyltransferase 9 |
NCBI Synonym Full Names: | polypeptide N-acetylgalactosaminyltransferase 9 |
NCBI Official Symbol: | GALNT9 |
NCBI Official Synonym Symbols: | GALNACT9; GALNAC-T9 |
NCBI Protein Information: | polypeptide N-acetylgalactosaminyltransferase 9 |
UniProt Protein Name: | Polypeptide N-acetylgalactosaminyltransferase 9 |
UniProt Synonym Protein Names: | Polypeptide GalNAc transferase 9; GalNAc-T9; pp-GaNTase 9; Protein-UDP acetylgalactosaminyltransferase 9; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9 |
Protein Family: | Polypeptide N-acetylgalactosaminyltransferase |
UniProt Gene Name: | GALNT9 |
UniProt Entry Name: | GALT9_HUMAN |