GAD2 Antibody, HRP conjugated (PACO52087)
- SKU:
- PACO52087
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | GAD2 Antibody, HRP conjugated (PACO52087) |
抗体コード: | PACO52087 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Glutamate decarboxylase 2 protein (1-82AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Catalyzes the production of GABA. |
シノニム: | Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid, decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform), GAD2, GAD65 |
UniProt Protein Function: | GAD2: Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family. |
UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - taurine and hypotaurine; Lyase; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Amino Acid Metabolism - alanine, aspartate and glutamate Chromosomal Location of Human Ortholog: 10p11.23 Cellular Component: presynaptic membrane; Golgi membrane; synaptic vesicle membrane; axon; perinuclear region of cytoplasm; plasma membrane; cytosol; cell junction Molecular Function:protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; pyridoxal phosphate binding Biological Process: response to drug; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; neurotransmitter biosynthetic process |
NCBI Summary: | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q05329 |
NCBI GenInfo Identifier: | 1352216 |
NCBI Gene ID: | 2572 |
NCBI Accession: | Q05329.1 |
UniProt Related Accession: | Q05329 |
Molecular Weight: | |
NCBI Full Name: | Glutamate decarboxylase 2 |
NCBI Synonym Full Names: | glutamate decarboxylase 2 |
NCBI Official Symbol: | GAD2 |
NCBI Official Synonym Symbols: | GAD65 |
NCBI Protein Information: | glutamate decarboxylase 2 |
UniProt Protein Name: | Glutamate decarboxylase 2 |
UniProt Synonym Protein Names: | 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform |
Protein Family: | Glutamate decarboxylase |
UniProt Gene Name: | GAD2 |
UniProt Entry Name: | DCE2_HUMAN |