UniProt Protein Function: | GABRQ: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xq28 Cellular Component: integral to plasma membrane; plasma membrane; receptor complex Molecular Function:GABA-A receptor activity; neurotransmitter transporter activity; transmembrane receptor activity Biological Process: signal transduction |
NCBI Summary: | The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009] |
UniProt Code: | Q9UN88 |
NCBI GenInfo Identifier: | 13959382 |
NCBI Gene ID: | 55879 |
NCBI Accession: | Q9UN88.2 |
UniProt Secondary Accession: | Q9UN88,Q32MB4, Q9NZK8, A6NFN1, |
UniProt Related Accession: | Q9UN88 |
Molecular Weight: | 72,022 Da |
NCBI Full Name: | Gamma-aminobutyric acid receptor subunit theta |
NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor theta subunit |
NCBI Official Symbol: | GABRQ |
NCBI Official Synonym Symbols: | THETA |
NCBI Protein Information: | gamma-aminobutyric acid receptor subunit theta |
UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit theta |
UniProt Synonym Protein Names: | GABA(A) receptor subunit theta |
Protein Family: | Gamma-aminobutyric acid receptor |
UniProt Gene Name: | GABRQ |
UniProt Entry Name: | GBRT_HUMAN |