GABARAPL2 Antibody (PACO09379)
- SKU:
- PACO09379
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GABARAPL2 Antibody (PACO09379) |
抗体コード: | PACO09379 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human GABARAPL2 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | GABA(A) receptor-associated protein-like 2;GABARAPL2;ATG8;GATE-16;GATE16;GEF2 ; |
UniProt Protein Function: | GABARAPL2: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Implicated in intra-Golgi transport and post-mitotic Golgi re-assembly. Modulates the activity of SNAREs in the Golgi apparatus and is therefore an essential component of intra-Golgi transport and post-mitotic Golgi re-assembly. It first stimulates the ATPase activity of NSF, which in turn stimulates the association with GOSR1. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin. Interacts with ULK1. Phosphorylated upon DNA damage, probably by ATM or ATR. |
UniProt Protein Details: | Protein type:Vesicle; Microtubule-binding; Ubiquitin-like modifier; Autophagy; Adaptor/scaffold Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: autophagic vacuole; cytoplasm; cytosol; Golgi apparatus; Golgi membrane; intracellular Molecular Function:ATPase binding; beta-tubulin binding; GABA receptor binding; protein binding; SNARE binding; ubiquitin protein ligase binding Biological Process: autophagic vacuole formation; cellular response to nitrogen starvation; intra-Golgi vesicle-mediated transport; macroautophagy; mitochondrion degradation; positive regulation of ATPase activity |
UniProt Code: | P60520 |
NCBI GenInfo Identifier: | 44888808 |
NCBI Gene ID: | 11345 |
NCBI Accession: | P60520.1 |
UniProt Secondary Accession: | P60520,O08765, Q6FG91, Q9DCP8, Q9UQF7, |
UniProt Related Accession: | P60520 |
Molecular Weight: | 13,667 Da |
NCBI Full Name: | Gamma-aminobutyric acid receptor-associated protein-like 2 |
NCBI Synonym Full Names: | GABA type A receptor associated protein like 2 |
NCBI Official Symbol: | GABARAPL2 |
NCBI Official Synonym Symbols: | ATG8; GEF2; ATG8C; GEF-2; GATE16; GATE-16 |
NCBI Protein Information: | gamma-aminobutyric acid receptor-associated protein-like 2 |
UniProt Protein Name: | Gamma-aminobutyric acid receptor-associated protein-like 2 |
UniProt Synonym Protein Names: | GABA(A) receptor-associated protein-like 2; Ganglioside expression factor 2; GEF-2; General protein transport factor p16; Golgi-associated ATPase enhancer of 16 kDa; GATE-16; MAP1 light chain 3-related protein |
Protein Family: | Gamma-aminobutyric acid receptor-associated protein |
UniProt Gene Name: | GABARAPL2 |
UniProt Entry Name: | GBRL2_HUMAN |