FZD4 Antibody (PACO05441)
- SKU:
- PACO05441
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | FZD4 Antibody (PACO05441) |
抗体コード: | PACO05441 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:5000, IF:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from the Internal region of human Frizzled-4. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | FZD4; Frizzled-4; Fz-4; hFz4; FzE4; CD antigen CD344 |
UniProt Protein Function: | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
NCBI Summary: | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9ULV1 |
NCBI GenInfo Identifier: | 62298045 |
NCBI Gene ID: | 8322 |
NCBI Accession: | Q9ULV1.2 |
UniProt Secondary Accession: | Q9ULV1,Q14C97, Q6S9E4, A8K9Q3, |
UniProt Related Accession: | Q9ULV1 |
Molecular Weight: | 59,881 Da |
NCBI Full Name: | Frizzled-4 |
NCBI Synonym Full Names: | frizzled class receptor 4 |
NCBI Official Symbol: | FZD4 |
NCBI Official Synonym Symbols: | Fz4; EVR1; FEVR; Fz-4; FzE4; GPCR; hFz4; CD344; FZD4S |
NCBI Protein Information: | frizzled-4 |
UniProt Protein Name: | Frizzled-4 |
UniProt Synonym Protein Names: | FzE4; CD_antigen: CD344 |
UniProt Gene Name: | FZD4 |