FOXC1 Antibody (PACO48594)
- SKU:
- PACO48594
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | FOXC1 Antibody (PACO48594) |
抗体コード: | PACO48594 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Forkhead box protein C1 protein (1-79AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: MCF-7 whole cell lysate, HepG2 whole cell lysate. All lanes: FOXC1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 57 kDa. Observed band size: 57 kDa.. | |
Immunofluorescent analysis of Hela cells using PACO48594 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye. |
シノニム: | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3), FOXC1, FKHL7 FREAC3 |
UniProt Protein Function: | FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Cell cycle regulation; Cell development/differentiation Chromosomal Location of Human Ortholog: 6p25 Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus Molecular Function:DNA bending activity; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding Biological Process: cell migration; cell proliferation; eye development; heart development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1 |
NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q12948 |
NCBI GenInfo Identifier: | 13638267 |
NCBI Gene ID: | 2296 |
NCBI Accession: | Q12948.3 |
UniProt Secondary Accession: | Q12948,Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06, |
UniProt Related Accession: | Q12948 |
Molecular Weight: | 56,789 Da |
NCBI Full Name: | Forkhead box protein C1 |
NCBI Synonym Full Names: | forkhead box C1 |
NCBI Official Symbol: | FOXC1 |
NCBI Official Synonym Symbols: | ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3 |
NCBI Protein Information: | forkhead box protein C1 |
UniProt Protein Name: | Forkhead box protein C1 |
UniProt Synonym Protein Names: | Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3 |
Protein Family: | Forkhead box protein |
UniProt Gene Name: | FOXC1 |
UniProt Entry Name: | FOXC1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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