FOXA3 Antibody (PACO59724)
- SKU:
- PACO59724
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | FOXA3 Antibody (PACO59724) |
抗体コード: | PACO59724 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
反応性: | Human |
免疫原: | Recombinant Human Hepatocyte nuclear factor 3-γ protein (220-336AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO59724 diluted at 1:700 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. |
シノニム: | Hepatocyte nuclear factor 3-γ (HNF-3-gamma) (HNF-3G) (Fork head-related protein FKH H3) (Forkhead box protein A3) (Transcription factor 3G) (TCF-3G), FOXA3, HNF3G TCF3G |
UniProt Protein Function: | FOXA3: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 19q13.32 Molecular Function:transcription factor activity Biological Process: cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008] |
UniProt Code: | P55318 |
NCBI GenInfo Identifier: | 16359111 |
NCBI Gene ID: | 3171 |
NCBI Accession: | BC016024 |
UniProt Secondary Accession: | P55318,Q53F16, Q9UMW9, A9LYI5, |
UniProt Related Accession: | P55318 |
Molecular Weight: | 37,140 Da |
NCBI Full Name: | Homo sapiens forkhead box A3, mRNA |
NCBI Synonym Full Names: | forkhead box A3 |
NCBI Official Symbol: | FOXA3 |
NCBI Official Synonym Symbols: | FKHH3; HNF3G; TCF3G |
NCBI Protein Information: | hepatocyte nuclear factor 3-gamma |
UniProt Protein Name: | Hepatocyte nuclear factor 3-gamma |
UniProt Synonym Protein Names: | Fork head-related protein FKH H3; Forkhead box protein A3; Transcription factor 3G; TCF-3G |
Protein Family: | Hepatocyte nuclear factor |
UniProt Gene Name: | FOXA3 |
UniProt Entry Name: | FOXA3_HUMAN |
Antibodies |
Anti-FOXA3 Antibody (CAB16382) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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