FKBP8 Antibody (PACO49174)
- SKU:
- PACO49174
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | FKBP8 Antibody (PACO49174) |
抗体コード: | PACO49174 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP8 protein (58-190AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Jurkat whole cell lysate, Hela whole cell lysate, SH-SY5Y whole cell lysate, HEK293 whole cell lysate, Mouse liver tissue. All lanes: FKBP8 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45, 28 kDa. Observed band size: 55 kDa.. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO49174 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO49174 at dilution of 1:100. |
バックグラウンド: | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. |
シノニム: | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase), FKBP8, FKBP38 |
UniProt Protein Function: | FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Chaperone; Isomerase; Mitochondrial; EC 5.2.1.8; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p12 Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrial membrane; integral to endoplasmic reticulum membrane Molecular Function:identical protein binding; protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; metal ion binding Biological Process: smoothened signaling pathway; camera-type eye development; protein peptidyl-prolyl isomerization; viral reproduction; apoptosis; regulation of gene expression; multicellular organism growth; cell fate specification; positive regulation of BMP signaling pathway; dorsoventral neural tube patterning; negative regulation of apoptosis |
NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14318 |
NCBI GenInfo Identifier: | 193806337 |
NCBI Gene ID: | 23770 |
NCBI Accession: | Q14318.2 |
UniProt Related Accession: | Q14318 |
Molecular Weight: | 55kDa |
NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP8 |
NCBI Synonym Full Names: | FKBP prolyl isomerase 8 |
NCBI Official Symbol: | FKBP8 |
NCBI Official Synonym Symbols: | FKBP38; FKBPr38 |
NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP8 |
UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP8 |
UniProt Synonym Protein Names: | 38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase |
Protein Family: | Peptidyl-prolyl cis-trans isomerase |
UniProt Gene Name: | FKBP8 |
UniProt Entry Name: | FKBP8_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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