FKBP6 Antibody, HRP conjugated (PACO26782)
- SKU:
- PACO26782
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | FKBP6 Antibody, HRP conjugated (PACO26782) |
抗体コード: | PACO26782 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Inactive peptidyl-prolyl cis-trans isomerase FKBP6 protein (101-327AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. |
シノニム: | Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36), FKBP6, FKBP36 |
UniProt Protein Function: | FKBP6: PPIases accelerate the folding of proteins. FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Isomerase; EC 5.2.1.8 Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: endoplasmic reticulum membrane; cytoplasm; synaptonemal complex; cytosol Molecular Function:protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; Hsp90 protein binding Biological Process: meiosis; protein peptidyl-prolyl isomerization; protein folding; DNA methylation during gametogenesis; spermatogenesis; RNA-mediated gene silencing; cell differentiation |
NCBI Summary: | The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
UniProt Code: | O75344 |
NCBI GenInfo Identifier: | 13124184 |
NCBI Gene ID: | 8468 |
NCBI Accession: | O75344.1 |
UniProt Related Accession: | O75344 |
Molecular Weight: | ~ 37kDa |
NCBI Full Name: | Inactive peptidyl-prolyl cis-trans isomerase FKBP6 |
NCBI Synonym Full Names: | FKBP prolyl isomerase 6 |
NCBI Official Symbol: | FKBP6 |
NCBI Official Synonym Symbols: | FKBP36 |
NCBI Protein Information: | inactive peptidyl-prolyl cis-trans isomerase FKBP6 |
UniProt Protein Name: | Inactive peptidyl-prolyl cis-trans isomerase FKBP6 |
UniProt Synonym Protein Names: | 36 kDa FK506-binding protein; 36 kDa FKBP; FKBP-36; FK506-binding protein 6; FKBP-6; Immunophilin FKBP36 |
Protein Family: | FK506-binding protein |
UniProt Gene Name: | FKBP6 |
UniProt Entry Name: | FKBP6_HUMAN |