FBXO25 Antibody (PACO39482)
- SKU:
- PACO39482
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | FBXO25 Antibody (PACO39482) |
抗体コード: | PACO39482 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human F-box only protein 25 protein (1-291AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: FBXO25 antibody at 3µg/ml. Lane 1: Mouse liver tissue. Lane 2: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 44, 43, 35 kDa. Observed band size: 44 kDa. | |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO39482 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO39482 at dilution of 1:100. |
バックグラウンド: | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT). |
シノニム: | F-box only protein 25, FBXO25, FBX25 |
UniProt Protein Function: | FBXO25: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT). A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 8p23.3 Cellular Component: nucleolus; nucleus; SCF ubiquitin ligase complex; ubiquitin ligase complex Molecular Function:actin binding; protein binding; ubiquitin-protein ligase activity Biological Process: protein ubiquitination |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8TCJ0 |
NCBI GenInfo Identifier: | 34878757 |
NCBI Gene ID: | 26260 |
NCBI Accession: | NP_036305.2 |
UniProt Secondary Accession: | Q8TCJ0,Q6PJ83, Q7Z4V4, Q9UKB8, |
UniProt Related Accession: | Q8TCJ0 |
Molecular Weight: | |
NCBI Full Name: | F-box only protein 25 isoform 3 |
NCBI Synonym Full Names: | F-box protein 25 |
NCBI Official Symbol: | FBXO25 |
NCBI Official Synonym Symbols: | FBX25 |
NCBI Protein Information: | F-box only protein 25 |
UniProt Protein Name: | F-box only protein 25 |
Protein Family: | F-box only protein |
UniProt Gene Name: | FBXO25 |
UniProt Entry Name: | FBX25_HUMAN |
Antibodies |
Anti-FBXO25 Antibody (CAB15150) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |