FAIM2 Antibody (PACO16299)
- SKU:
- PACO16299
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | FAIM2 Antibody (PACO16299) |
抗体コード: | PACO16299 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human FAIM2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16299(FAIM2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A172 cells, Raji cells, Primary antibody: PACO16299(FAIM2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16299(FAIM2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | FAIM2 (Fas apoptotic inhibitory molecule 2), also known as LFG (Protein lifeguard), TMBIM2 (Transmembrane BAX inhibitor motif-containing protein 2) and NMP35 (neural membrane protein 35), is a 316 amino acid, multipass membrane protein that uniquely protects cells from Fas-induced apoptosis. Though widely expressed, FAIM2 expression is highest in hippocampus. FAIM2 contains seven transmembrane domains and resembles Bax Inhibitor-1, another anti-apoptotic protein. |
シノニム: | Fas apoptotic inhibitory molecule 2 |
UniProt Protein Function: | FAIM2: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Belongs to the BI1 family. LFG subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 12q13 Cellular Component: postsynaptic membrane; integral to membrane; cell junction; lipid raft Biological Process: cerebellar granular layer development; apoptosis; regulation of neuron apoptosis; cerebellar Purkinje cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; negative regulation of neuron apoptosis; negative regulation of apoptosis |
UniProt Code: | Q9BWQ8 |
NCBI GenInfo Identifier: | 38503167 |
NCBI Gene ID: | 23017 |
NCBI Accession: | Q9BWQ8.1 |
UniProt Secondary Accession: | Q9BWQ8,Q9UJY9, Q9Y2F7, A8K1W6, B3KR08, |
UniProt Related Accession: | Q9BWQ8 |
Molecular Weight: | 316 |
NCBI Full Name: | Protein lifeguard 2 |
NCBI Synonym Full Names: | Fas apoptotic inhibitory molecule 2 |
NCBI Official Symbol: | FAIM2 |
NCBI Official Synonym Symbols: | LFG; LFG2; NGP35; NMP35; TMBIM2 |
NCBI Protein Information: | protein lifeguard 2; neural membrane protein 35; transmembrane BAX inhibitor motif-containing protein 2 |
UniProt Protein Name: | Protein lifeguard 2 |
UniProt Synonym Protein Names: | Fas apoptotic inhibitory molecule 2; Neural membrane protein 35; Transmembrane BAX inhibitor motif-containing protein 2 |
Protein Family: | Protein lifeguard |
UniProt Gene Name: | FAIM2 |
UniProt Entry Name: | LFG2_HUMAN |