UniProt Protein Function: | FABP2: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q28-q31 Cellular Component: cytoplasm Molecular Function:transporter activity; fatty acid binding Biological Process: transport; digestion |
NCBI Summary: | The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008] |
UniProt Code: | P12104 |
NCBI GenInfo Identifier: | 119805 |
NCBI Gene ID: | 2169 |
NCBI Accession: | P12104.2 |
UniProt Secondary Accession: | P12104,Q2NKJ1, |
UniProt Related Accession: | P12104 |
Molecular Weight: | 132 |
NCBI Full Name: | Fatty acid-binding protein, intestinal |
NCBI Synonym Full Names: | fatty acid binding protein 2, intestinal |
NCBI Official Symbol: | FABP2 |
NCBI Official Synonym Symbols: | FABPI; I-FABP |
NCBI Protein Information: | fatty acid-binding protein, intestinal; fatty acid-binding protein 2; intestinal-type fatty acid-binding protein |
UniProt Protein Name: | Fatty acid-binding protein, intestinal |
UniProt Synonym Protein Names: | Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP |
Protein Family: | Fatty acid-binding protein |
UniProt Gene Name: | FABP2 |
UniProt Entry Name: | FABPI_HUMAN |