F9 Antibody (PACO21155)
- SKU:
- PACO21155
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | F9 Antibody (PACO21155) |
抗体コード: | PACO21155 |
サイズ: | 100ul(100ug) |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant protein of human F9 |
憲法: | Liquid |
ストレージバッファ: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts of HO-8910 cell lines, using F9 antibody. |
バックグラウンド: | This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. |
シノニム: | F9;FIX;HEMB;MGC129641;MGC129642;P19;PTC |
UniProt Protein Function: | F9: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB); also known as Christmas disease. Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide. Defects in F9 are the cause of thrombophilia due to factor IX defect (THPH8). A hemostatic disorder characterized by a tendency to thrombosis. Belongs to the peptidase S1 family. |
UniProt Protein Details: | Protein type:Secreted; Protease; EC 3.4.21.22; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xq27.1-q27.2 Cellular Component: Golgi lumen; endoplasmic reticulum lumen; extracellular region; plasma membrane Molecular Function:serine-type endopeptidase activity; calcium ion binding Biological Process: blood coagulation, extrinsic pathway; cellular protein metabolic process; blood coagulation; post-translational protein modification; proteolysis; blood coagulation, intrinsic pathway; peptidyl-glutamic acid carboxylation Disease: Hemophilia B; Thrombophilia, X-linked, Due To Factor Ix Defect; Coumarin Resistance |
NCBI Summary: | This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq, Jul 2008] |
UniProt Code: | P00740 |
NCBI GenInfo Identifier: | 67476446 |
NCBI Gene ID: | 2158 |
NCBI Accession: | P00740.2 |
UniProt Secondary Accession: | P00740,Q5FBE1, Q5JYJ8, A8K9N4, F2RM36, |
UniProt Related Accession: | P00740 |
Molecular Weight: | 461 |
NCBI Full Name: | Coagulation factor IX |
NCBI Synonym Full Names: | coagulation factor IX |
NCBI Official Symbol: | F9 |
NCBI Official Synonym Symbols: | FIX; P19; PTC; HEMB; THPH8 |
NCBI Protein Information: | coagulation factor IX; F9 p22; FIX F9; factor 9; factor IX F9; Christmas factor; plasma thromboplastic component; plasma thromboplastin component |
UniProt Protein Name: | Coagulation factor IX |
UniProt Synonym Protein Names: | Christmas factor; Plasma thromboplastin component; PTC |
Protein Family: | F9 protein |
UniProt Gene Name: | F9 |
UniProt Entry Name: | FA9_HUMAN |
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