F13A1 Antibody (PACO18969)
- SKU:
- PACO18969
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | F13A1 Antibody (PACO18969) |
抗体コード: | PACO18969 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human F13A1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18969(F13A1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18969(F13A1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the α chains of fibrin. |
シノニム: | coagulation factor XIII, A1 polypeptide |
UniProt Protein Function: | F13A1: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD). FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. Belongs to the transglutaminase superfamily. Transglutaminase family. |
UniProt Protein Details: | Protein type:Transferase; EC 2.3.2.13 Chromosomal Location of Human Ortholog: 6p25.3-p24.3 Cellular Component: extracellular region Molecular Function:protein-glutamine gamma-glutamyltransferase activity; metal ion binding Biological Process: platelet activation; platelet degranulation; peptide cross-linking; blood coagulation Disease: Thrombophilia Due To Thrombin Defect; Myocardial Infarction, Susceptibility To; Factor Xiii, A Subunit, Deficiency Of |
NCBI Summary: | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008] |
UniProt Code: | P00488 |
NCBI GenInfo Identifier: | 119395709 |
NCBI Gene ID: | 2162 |
NCBI Accession: | NP_000120.2 |
UniProt Secondary Accession: | P00488,Q59HA7, Q8N6X2, Q96P24, Q9BX29, |
UniProt Related Accession: | P00488 |
Molecular Weight: | 312,000 |
NCBI Full Name: | coagulation factor XIII A chain |
NCBI Synonym Full Names: | coagulation factor XIII, A1 polypeptide |
NCBI Official Symbol: | F13A1 |
NCBI Official Synonym Symbols: | F13A |
NCBI Protein Information: | coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit; coagulation factor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase A chain; bA525O21.1 (coagulation factor XIII, A1 polypeptide) |
UniProt Protein Name: | Coagulation factor XIII A chain |
UniProt Synonym Protein Names: | Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain |
Protein Family: | 36 kDa major membrane protein |
UniProt Gene Name: | F13A1 |
UniProt Entry Name: | F13A_HUMAN |
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