EXO1 Antibody, HRP conjugated (PACO26582)
- SKU:
- PACO26582
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | EXO1 Antibody, HRP conjugated (PACO26582) |
抗体コード: | PACO26582 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Exonuclease 1 protein (301-600AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. |
シノニム: | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI), EXO1, EXOI HEX1 |
UniProt Protein Function: | EXO1: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.-.-; Hydrolase Chromosomal Location of Human Ortholog: 1q43 Cellular Component: nucleoplasm; nucleus Molecular Function:5'-3' exonuclease activity; protein binding; double-stranded DNA specific 5'-3' exodeoxyribonuclease activity; structure-specific DNA binding; DNA binding; 5'-3' exodeoxyribonuclease activity; single-stranded DNA specific 5'-3' exodeoxyribonuclease activity; metal ion binding; exonuclease activity; ribonuclease H activity; flap endonuclease activity Biological Process: humoral immune response mediated by circulating immunoglobulin; mismatch repair; meiotic cell cycle; somatic hypermutation of immunoglobulin genes; isotype switching; DNA repair; DNA catabolic process, exonucleolytic; DNA catabolic process, endonucleolytic; DNA recombination |
NCBI Summary: | This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UQ84 |
NCBI GenInfo Identifier: | 85700954 |
NCBI Gene ID: | 9156 |
NCBI Accession: | Q9UQ84.2 |
UniProt Secondary Accession: | Q9UQ84,O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38 Q9UNW0, |
UniProt Related Accession: | Q9UQ84 |
Molecular Weight: | 846 |
NCBI Full Name: | Exonuclease 1 |
NCBI Synonym Full Names: | exonuclease 1 |
NCBI Official Symbol: | EXO1 |
NCBI Official Synonym Symbols: | HEX1; hExoI |
NCBI Protein Information: | exonuclease 1; hExo1; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1 |
UniProt Protein Name: | Exonuclease 1 |
UniProt Synonym Protein Names: | Exonuclease I; hExoI |
Protein Family: | Exonuclease |
UniProt Gene Name: | EXO1 |
UniProt Entry Name: | EXO1_HUMAN |