EPS15L1 Antibody (PACO15605)
- SKU:
- PACO15605
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | EPS15L1 Antibody (PACO15605) |
抗体コード: | PACO15605 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human EPS15L1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15605(EPS15L1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, PC3 cells, 231 cells, 293T cells, Primary antibody: PACO15605(EPS15L1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15605(EPS15L1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Epidermal growth factor receptor substrate 15-like 1 is a protein that in humans is encoded by the EPS15L1gene. Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) By similarity. Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2. |
シノニム: | epidermal growth factor receptor pathway substrate 15-like 1 |
UniProt Protein Function: | EPS15R: epidermal growth factor receptor substrate protein 15R. Contains three EH domains which are implicated in endocytosis, vesicle transport and signal transduction. All three EH domains contain calcium-binding domains ofthe EF-hand type. Contains 2 UIM motifs, which are is responsible for ubiquitin recognition and monoubiquitination. May function as an adaptor between ubiquitinated proteins and the clathrin coat or other endocytic scaffolds. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Vesicle Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: membrane; plasma membrane; coated pit; nucleus Molecular Function:protein binding; calcium ion binding Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; endocytosis |
UniProt Code: | Q9UBC2 |
NCBI GenInfo Identifier: | 385428859 |
NCBI Gene ID: | 58513 |
NCBI Accession: | NP_001245303.1 |
UniProt Related Accession: | Q9UBC2 |
Molecular Weight: | |
NCBI Full Name: | epidermal growth factor receptor substrate 15-like 1 isoform 1 |
NCBI Synonym Full Names: | epidermal growth factor receptor pathway substrate 15 like 1 |
NCBI Official Symbol: | EPS15L1 |
NCBI Official Synonym Symbols: | EPS15R |
NCBI Protein Information: | epidermal growth factor receptor substrate 15-like 1 |
UniProt Protein Name: | Epidermal growth factor receptor substrate 15-like 1 |
UniProt Synonym Protein Names: | Eps15-related protein |
UniProt Gene Name: | EPS15L1 |
UniProt Entry Name: | EP15R_HUMAN |