ENTPD5 Antibody (PACO43734)
- SKU:
- PACO43734
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ENTPD5 Antibody (PACO43734) |
抗体コード: | PACO43734 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IP |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Ectonucleoside triphosphate diphosphohydrolase 5 protein (149-428AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: ENTPD5 antibody at 4µg/ml. Lane 1: Mouse liver tissue. Lane 2: Mouse kidney tissue. Lane 3: Mouse gonad tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 48 kDa. Observed band size: 48 kDa. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43734 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO43734 at dilution of 1:100. |
バックグラウンド: | Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. |
シノニム: | Ectonucleoside triphosphate diphosphohydrolase 5 (NTPDase 5) (EC 3.6.1.6) (CD39 antigen-like 4) (ER-UDPase) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (EC 3.6.1.42) (Nucleoside diphosphatase) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5), ENTPD5, CD39L4 PCPH |
UniProt Protein Function: | ENTPD5: Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. Belongs to the GDA1/CD39 NTPase family. |
UniProt Protein Details: | Protein type:Hydrolase; Nucleotide Metabolism - pyrimidine; Oncoprotein; EC 3.6.1.6; EC 3.6.1.42; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 14q24 Cellular Component: endoplasmic reticulum Molecular Function:guanosine-diphosphatase activity; protein binding; uridine-diphosphatase activity Biological Process: 'de novo' posttranslational protein folding; ATP metabolic process; cell growth; cell proliferation; positive regulation of glycolysis; protein amino acid N-linked glycosylation; regulation of phosphoinositide 3-kinase cascade |
NCBI Summary: | The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009] |
UniProt Code: | O75356 |
NCBI GenInfo Identifier: | 18202142 |
NCBI Gene ID: | 957 |
NCBI Accession: | O75356.1 |
UniProt Secondary Accession: | O75356,Q96RX0, A1L4C5, |
UniProt Related Accession: | O75356 |
Molecular Weight: | 47,517 Da |
NCBI Full Name: | Ectonucleoside triphosphate diphosphohydrolase 5 |
NCBI Synonym Full Names: | ectonucleoside triphosphate diphosphohydrolase 5 |
NCBI Official Symbol: | ENTPD5 |
NCBI Official Synonym Symbols: | PCPH; CD39L4; NTPDase-5 |
NCBI Protein Information: | ectonucleoside triphosphate diphosphohydrolase 5 |
UniProt Protein Name: | Ectonucleoside triphosphate diphosphohydrolase 5 |
UniProt Synonym Protein Names: | CD39 antigen-like 4; ER-UDPase; Guanosine-diphosphatase ENTPD5 (EC:3.6.1.42); GDPase ENTPD5; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5; UDPase ENTPD5 |
Protein Family: | Ectonucleoside triphosphate diphosphohydrolase |
UniProt Gene Name: | ENTPD5 |
UniProt Entry Name: | ENTP5_HUMAN |
Antibodies | ELISA Kits |
Anti-ENTPD5 Antibody (CAB8108) | Human Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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