ENPP2 Antibody (PACO02047)
- SKU:
- PACO02047
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | ENPP2 Antibody |
抗体コード: | PACO02047 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the Internal region of human Autotaxin. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | ENPP2; ATX; PDNP2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; Autotaxin; Extracellular lysophospholipase D; LysoPLD |
UniProt Protein Function: | ENPP2: Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid Metabolism - ether lipid; Phosphodiesterase; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; EC 3.1.4.39 Chromosomal Location of Human Ortholog: 8q24.1 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane Molecular Function:nucleotide diphosphatase activity; phosphodiesterase I activity; nucleic acid binding; hydrolase activity; zinc ion binding; calcium ion binding; transcription factor binding; scavenger receptor activity; alkylglycerophosphoethanolamine phosphodiesterase activity; polysaccharide binding; lysophospholipase activity Biological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; phospholipid catabolic process; immune response; cell motility; chemotaxis; regulation of angiogenesis; phosphate metabolic process; regulation of cell migration |
NCBI Summary: | The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008] |
UniProt Code: | Q13822 |
NCBI GenInfo Identifier: | 290457674 |
NCBI Gene ID: | 5168 |
NCBI Accession: | Q13822.3 |
UniProt Related Accession: | Q13822 |
Molecular Weight: | |
NCBI Full Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
NCBI Synonym Full Names: | ectonucleotide pyrophosphatase/phosphodiesterase 2 |
NCBI Official Symbol: | ENPP2 |
NCBI Official Synonym Symbols: | ATX; NPP2; ATX-X; PDNP2; LysoPLD; AUTOTAXIN; PD-IALPHA |
NCBI Protein Information: | ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
UniProt Protein Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
UniProt Synonym Protein Names: | Autotaxin; Extracellular lysophospholipase D; LysoPLD |
UniProt Gene Name: | ENPP2 |
UniProt Entry Name: | ENPP2_HUMAN |