EMD Antibody (PACO16256)
- SKU:
- PACO16256
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | EMD Antibody (PACO16256) |
抗体コード: | PACO16256 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
反応性: | Human |
免疫原: | Fusion protein of human EMD |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, A549 cells, Primary antibody: PACO16256(EMD Antibody) at dilution 1/1600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. |
バックグラウンド: | Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. |
シノニム: | emerin |
UniProt Protein Function: | emerin: a single pass membrane protein that spans the inner nuclear membrane. A serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It interacts with lamins A and C, and mediates membrane anchorage to the cytoskeleton. Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through an exportin 1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Colocalized with BAF at the central region of the assembling nuclear rim, near spindle-attachment sites. Hyper-phosphorylated on tyrosine in cells overexpressing HER2. Directly phosphorylated by Src and Abl. Phosphorylated by Src at Y59, Y74 and Y95. May function as a downstream effector and signal integrator for tyrosine kinase signaling pathways at the nuclear envelope. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. |
UniProt Protein Details: | Protein type:Cytoskeletal; Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 Cellular Component: microtubule; nuclear outer membrane; nuclear membrane; membrane; endoplasmic reticulum; integral to membrane; nuclear inner membrane; nuclear envelope Molecular Function:protein binding; beta-tubulin binding; actin binding Biological Process: positive regulation of protein export from nucleus; mitotic nuclear envelope reassembly; muscle development; muscle contraction; negative regulation of fibroblast proliferation; mitotic nuclear envelope disassembly; mitotic cell cycle Disease: Emery-dreifuss Muscular Dystrophy 1, X-linked |
NCBI Summary: | Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P50402 |
NCBI GenInfo Identifier: | 1706639 |
NCBI Gene ID: | 2010 |
NCBI Accession: | P50402.1 |
UniProt Secondary Accession: | P50402,Q6FI02, |
UniProt Related Accession: | P50402 |
Molecular Weight: | |
NCBI Full Name: | Emerin |
NCBI Synonym Full Names: | emerin |
NCBI Official Symbol: | EMD |
NCBI Official Synonym Symbols: | STA; EDMD; LEMD5 |
NCBI Protein Information: | emerin; LEM domain containing 5 |
UniProt Protein Name: | Emerin |
Protein Family: | Emerin |
UniProt Gene Name: | EMD |
UniProt Entry Name: | EMD_HUMAN |
Antibodies |
Anti-EMD Antibody (CAB1132) |
Anti-EMD Antibody (CAB13925) |
Anti-EMD Antibody (CAB18016)[KO Validated] |
Anti-EMD Antibody (CAB18030)[KO Validated] |
Anti-Emerin Antibody (CAB4187) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |