EFNB2 Antibody (PACO44155)
- SKU:
- PACO44155
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | EFNB2 Antibody (PACO44155) |
抗体コード: | PACO44155 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Ephrin-B2 protein (28-229AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: EFNB2 antibody at 6µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 37 kDa. Observed band size: 37 kDa.. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44155 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human skin tissue using PACO44155 at dilution of 1:100. |
バックグラウンド: | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. |
シノニム: | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L), EFNB2, EPLG5 HTKL LERK5 |
UniProt Protein Function: | EFNB2: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphA3 and EphB4. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B2 is implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. May play a role in constraining the orientation of longitudinally projecting axons |
UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Membrane protein, integral Chromosomal Location of Human Ortholog: 13q33 Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane Molecular Function:protein binding; ephrin receptor binding Biological Process: axon guidance; organ morphogenesis; anatomical structure morphogenesis; regulation of chemotaxis; viral reproduction; cell-cell signaling; cell migration during sprouting angiogenesis; ephrin receptor signaling pathway; cell adhesion; lymph vessel development |
NCBI Summary: | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008] |
UniProt Code: | P52799 |
NCBI GenInfo Identifier: | 1706673 |
NCBI Gene ID: | 1948 |
NCBI Accession: | P52799.1 |
UniProt Secondary Accession: | P52799,Q5JV56, |
UniProt Related Accession: | P52799 |
Molecular Weight: | 333 |
NCBI Full Name: | Ephrin-B2 |
NCBI Synonym Full Names: | ephrin-B2 |
NCBI Official Symbol: | EFNB2 |
NCBI Official Synonym Symbols: | HTKL; EPLG5; Htk-L; LERK5 |
NCBI Protein Information: | ephrin-B2; LERK-5; HTK ligand; ligand of eph-related kinase 5; eph-related receptor tyrosine kinase ligand 5 |
UniProt Protein Name: | Ephrin-B2 |
UniProt Synonym Protein Names: | EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L |
Protein Family: | Ephrin |
UniProt Gene Name: | EFNB2 |
UniProt Entry Name: | EFNB2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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