EDA2R Antibody (PACO16227)
- SKU:
- PACO16227
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | EDA2R Antibody (PACO16227) |
抗体コード: | PACO16227 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Fusion protein of human EDA2R |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16227(EDA2R Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: PACO16227(EDA2R Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16227(EDA2R Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene. |
シノニム: | ectodysplasin A2 receptor |
UniProt Protein Function: | Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016] |
UniProt Code: | Q9HAV5 |
NCBI GenInfo Identifier: | 313104030 |
NCBI Gene ID: | 60401 |
NCBI Accession: | Q9HAV5.2 |
UniProt Secondary Accession: | Q9HAV5,Q5VYX9, Q5VYY0, Q6UWM2, Q8IZA6 |
UniProt Related Accession: | Q9HAV5 |
Molecular Weight: | 32,959 Da |
NCBI Full Name: | Tumor necrosis factor receptor superfamily member 27 |
NCBI Synonym Full Names: | ectodysplasin A2 receptor |
NCBI Official Symbol: | EDA2R |
NCBI Official Synonym Symbols: | XEDAR; EDAA2R; EDA-A2R; TNFRSF27 |
NCBI Protein Information: | tumor necrosis factor receptor superfamily member 27 |
UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 27 |
UniProt Synonym Protein Names: | X-linked ectodysplasin-A2 receptor; EDA-A2 receptor |
Protein Family: | Tumor necrosis factor receptor superfamily |
UniProt Gene Name: | EDA2R |
UniProt Entry Name: |